A 46-year-old woman and nine-year-old girl have died in hospital after an Oshawa house fire on Wednesday morning, Durham Regional Police confirm.

A 56-year-old man and a 12-year-old child who were rescued from the home are in hospital in life-threatening condition.

Three police officers were also taken to hospital to be treated for smoke inhalation, Durham police said.

Oshawa Fire crews were called about a fire at 70 McGrigor Street at around 8:08 a.m., Wednesday morning.

They arrived within minutes, encountering heavy fire and smoke conditions.

Crews remain on scene fighting the blaze.

Centre Street South has been closed at John Street.

More to come